Transcriptome analyses reveal new insights on key determinants of perineural invasion in high-grade serous ovarian cancer

Perineural invasion (PNI) is a pathological feature of many cancers associated with poor outcomes, metastases, and recurrence. In relation to ovarian cancer (OC), there no information about PNI’s role mechanisms. Our study found that patients PNI-positive symptoms had significantly shorter overall survival (OS) time than PNI-negative symptoms. Multivariate analyses demonstrated PNI represented substantial independent prognostic factor in OC patients. At the transcriptome level, it noteworthy positivity was negatively correlated degree infiltration immune killer cells tumor tissues, including macrophage, central memory CD4 T-cell, natural cells, monocyte, T-cell. The results this revealed TAS2Rs proteins were markedly upregulated tissues predicted prognoses. Moreover, Immunohistochemical analysis TAS2R10 protein prognoses OC. Consequently, we for first powerful predictor prognosis analyzed its expression pattern some preliminary biochemical characterization, providing new clues guiding clinical prevention treatment